Clinical Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiencies

Scientific activity

Clinical Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiencies of Wroclaw Medical University

Main research areas:

HIV and AIDS infections:
Epidemiology, pathogenesis, prevention, clinic, diagnosis and treatment of HIV and AIDS infection:
The team of the Clinical Department collaborates with centres in Europe and the USA on the development of standards for antiretroviral treatment and other important trends in the HIV/AIDS epidemic, including co-morbidities, the impact of HIV on specific organs and systems, the efficacy and side effects of antiretroviral treatment.
- Parasitic infections in people living with HIV
- Assessment of metabolic disorders during antiretroviral therapy using selected markers.
- An important issue under investigation is the use and effectiveness of pre-exposure prophylaxis (PreP) in people at risk of HIV infection.

Sexually transmitted infections:
Prevention, diagnosis and treatment of sexually transmitted infections, in particular syphilis, chlamydiosis and gonorrhoea, also for people living with HIV and as part of PrEP.

COVID-19:
- epidemiology of SARS-CoV-2 infection in HIV-infected persons
- assessment of humoral and cellular response and efficacy of COVID-19 vaccination and adverse effects in the Lower Silesian population and in HIV-infected patients, using different types of Covid-19 vaccines
- COVID-19 (epidemiology, clinical picture, diagnosis, post-COVID and long COVID syndrome)

HEPATOLOGY:
- Infectious liver diseases caused by HAV, HBV, HCV, sequelae and complications
- Steatosis and non-alcoholic steatohepatitis- epidemiology and therapy

BORELIOSIS AND OTHER DISEASES OF ANIMALS:
Epidemiology, prevention, clinical picture, diagnosis and therapy

INTERNATIONAL COOPERATION:
START project - a prospective study evaluating the appropriateness of starting antiretroviral treatment in the early stages of HIV infection

LIST OF SELECTED PUBLICATIONS 2021 - SEPTEMBER 2022

1. COVID-19 vaccine candidates: a review. [AUTH.] MARTYNA BIAŁA, EDYTA LELONEK,  [CORRESPONDING AUTHOR] BRYGIDA KNYSZ. Post.Hig.Med.Dośw. 2021 Vol.75 pp.58-63,
2. Elderly patient care: a new reality of the SARS-CoV-2 pandemic. [CORRESPONDING AUTHOR] BEATA JANKOWSKA-POLAŃSKA, [AUTH.] KATHIE SARZYŃSKA, ALEKSANDRA PYTEL, DAMIAN IZBIAŃSKI, DAGMARA GAWEŁ-DĄBROWSKA, BRYGIDA KNYSZ. Aging Dis. 2021 Vol.12 no.7 pp.1554-1566,
3. HCV resistance-associated substitutions following direct-acting antiviral therapy failure - real-life data from Poland. [CORRESPONDING AUTHOR] MIŁOSZ PARCZEWSKI, [AUTH.] EWA JANCZEWSKA, ARKADIUSZ PISULA, DOROTA DYBOWSKA, WŁADYSŁAW ŁOJEWSKI, ADAM WITOR, MARTA WAWRZYNOWICZ-SYCZEWSKA, ŁUKASZ SOCHA, RAFAŁ KRYGIER, BRYGIDA KNYSZ, JOANNA MUSIALIK, ANNA URBAŃSKA, KAJA SCHEIBE, JERZY JAROSZEWICZ. Infect.Genet.Evol. 2021 Vol.93 art.104949 [9 p.],
4. ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials. [AUTH.] ROBERTO A. CALLE, NEETA B. AMIN, SANTOS CARVAJAL-GONZALEZ, TRENTON T. ROSS, ARTHUR BERGMAN, SUDEEPTA AGGARWAL, COLLIN CROWLEY, ANTHONY RINALDI, JESSICA MANCUSO, NARESH AGGARWAL, VEENA SOMAYAJI, MAŁGORZATA INGLOT, THERESA A. TUTHILL, KOU KOU, MAGALIE BOUCHER, GREG TESZ, ROBERT DULLEA, KENDRA K. BENCE, ALBERT M. KIM, JEFFREY A. PFEFFERKORN, [CORRESPONDING AUTHOR] WILLIAM P. ESLER. Nat.Med. 2021 Vol.27 no.10 pp.1836-1848,
5. Healthcare delivery for HIV‐positive people with tuberculosis in Europe. [CORRESPONDING AUTHOR] A.K. BENTZON, [AUTH.] A. PANTELEEV, V. MITSURA, E. BORODULINA, A. SKRAHINA, E. DENISOVA, S. TETRADOV, R. PODLASIN, V. RIEKSTINA, Z. KANCAUSKIENE, D. PADUTO, A. MOCROFT, T. TROFIMOVA, R. MILLER, F. POST, A. GREZESCZUK, J.D. LUNDGREN, M[AŁGORZATA] INGLOT, D. PODLEKAREVA, N. BOLOKADZE, O. KIRK. HIV Med. 2021 Vol.22 no.4 pp.283-293,
6. Acquired immune deficiency syndrome (AIDS) and late presentation in Poland - data from Test and Keep in Care (TAK) Polska project. [AUTH.] E. JABŁONOWSKA, [CORRESPONDING AUTHOR] B[ARTOSZ] SZETELA, [AUTH.] M. BIELECKI, A. HORBAN, M. BOCIAZGA-JASIK, E. MULARSKA, M. HLEBOWICZ, A. OLCZAK, M. PARCZEWSKI, A. GRZESZCZUK, D. BIELECKI, A. CYBULA, A. KOCBACH-PRZUDZIK, M. ANKIERSZTEJN-BARTCZAK, J.D. KOWALSKA. HIV Med. 2021 Vol.22 no.5 pp.387-396,
7. Convalescent plasma transfusion for the treatment of COVID-19 – experience from Poland: a multicenter study. [CORRESPONDING AUTHOR] ANNA MONIUSZKO-MALINOWSKA, [AUTH.] PIOTR CZUPRYNA, DOROTA ZARĘBSKA-MICHALUK, KRZYSZTOF TOMASIEWICZ, SŁAWOMIR PANCEWICZ, MARTA RORAT, ANNA DWORZAŃSKA, KATARZYNA SIKORSKA, BEATA BOLEWSKA, BEATA LORENC, ANDRZEJ CHCIAŁOWSKI, DOROTA KOZIELEWICZ, BARBARA OCZKO-GRZESIK, ANNA SZYMANEK-PASTERNAK, BARTOSZ SZETELA, MAGDALENA FIGLEROWICZ, MAGDALENA ROGALSKA, IZABELA ZALESKA, ROBERT FLISIAK. J.Clin.Med. 2021 Vol.10 no.1 art.28 [12 p.],
8. Impact of kidney failure on the severity of COVID-19. [CORRESPONDING AUTHOR] DOROTA ZARĘBSKA-MICHALUK, [AUTH.] JERZY JAROSZEWICZ, MAGDALENA ROGALSKA, BEATA LORENC, MARTA RORAT, ANNA SZYMANEK-PASTERNAK, ANNA PIEKARSKA, ALEKSANDRA BERKAN-KAWIŃSKA, KATARZYNA SIKORSKA, MAGDALENA TUDRUJEK-ZDUNEK, BARBARA OCZKO-GRZESIK, BEATA BOLEWSKA, PIOTR CZUPRYNA, DOROTA KOZIELEWICZ, JUSTYNA KOWALSKA, REGINA PODLASIN, KRZYSZTOF KŁOS, WŁODZIMIERZ MAZUR, PIOTR LESZCZYŃSKI, BARTOSZ SZETELA, KATARZYNA RECZKO, ROBERT FLISIAK. J.Clin.Med. 2021 Vol.10 no.9 art.2042 [14 p.],
9. Low prevalence of doravirine-associated resistance mutations among polish human immunodeficiency-1 (HIV-1)–infected patients. [AUTH.] KAJA SCHEIBE, ANNA URBAŃSKA, PAWEŁ JAKUBOWSKI, MARIA HLEBOWICZ, MONIKA BOCIĄGA-JASIK, ALEKSANDRA RACZYŃSKA, ALEKSANDRA SZYMCZAK, BARTOSZ SZETELA, WŁADYSŁAW ŁOJEWSKI, MIŁOSZ PARCZEWSKI. Antivir.Ther. 2021 Vol.26 no.3-5 pp.69-78,
10. Remdesivir-based therapy improved the recovery of patients with COVID-19 in the multicenter, real-world SARSTer study. [CORRESPONDING AUTHOR] ROBERT FLISIAK, [AUTH.] DOROTA ZARĘBSKA-MICHALUK, ALEKSANDRA BERKAN-KAWIŃSKA, MAGDALENA TUDRUJEK-ZDUNEK, MAGDALENA ROGALSKA, ANNA PIEKARSKA, DOROTA KOZIELEWICZ, KRZYSZTOF KŁOS, MARTA RORAT, BEATA BOLEWSKA, ANNA SZYMANEK-PASTERNAK, WŁODZIMIERZ MAZUR, BEATA LORENC, REGINA PODLASIN, KATARZYNA SIKORSKA, BARBARA OCZKO-GRZESIK, CEZARY IWASZKIEWICZ, BARTOSZ SZETELA, PAWEŁ PABJAN, MAŁGORZATA PAWŁOWSKA, KRZYSZTOF TOMASIEWICZ, JOANNA POLAŃSKA, JERZY JAROSZEWICZ. Pol.Arch.Med.Wewn. 2021 Vol.131 no.1 pp.103-110,
11. Low prevalence of doravirine-associated resistance mutations among polish human immunodeficiency-1 (HIV-1)–infected patients. [AUTH.] KAJA SCHEIBE, ANNA URBAŃSKA, PAWEŁ JAKUBOWSKI, MARIA HLEBOWICZ, MONIKA BOCIĄGA-JASIK, ALEKSANDRA RACZYŃSKA, ALEKSANDRA SZYMCZAK, BARTOSZ SZETELA, WŁADYSŁAW ŁOJEWSKI, MIŁOSZ PARCZEWSKI. Antivir.Ther. 2021 Vol.26 no.3-5 pp.69-78,
12. Five-year follow-up of cured HCV patients under real-world interferon-free therapy. [CORRESPONDING AUTHOR] ROBERT FLISIAK, [AUTH.] DOROTA ZARĘBSKA-MICHALUK, EWA JANCZEWSKA, TADEUSZ ŁAPIŃSKI, MAGDALENA ROGALSKA, EWA KARPIŃSKA, TOMASZ MIKUŁA, BEATA BOLEWSKA, JOLANTA BIAŁKOWSKA, KATARZYNA FLEISCHER-STĘPNIEWSKA, KRZYSZTOF TOMASIEWICZ, KORNELIA KARWOWSKA, MONIKA PAZGAN-SIMON, ANNA PIEKARSKA, HANNA BERAK, OLGA TRONINA, ALEKSANDER GARLICKI, JERZY JAROSZEWICZ. Cancers 2021 Vol.13 no.15 art.3694 [12 p.],
13. Asymptomatic human immunodeficiency virus-1 infection with high CD4+ T cell count does not alter iron metabolism or hepcidin levels: the pilot study. [AUTH.] ALEKSANDRA SZYMCZAK, MAŁGORZATA ZALEWSKA, WERONIKA RYMER, EWA A. JANKOWSKA. Infect.Dis.Ther. 2022 Vol.11 no.1 pp.265-275
14. Demographic and clinical overview of hospitalized COVID-19 patients during the first 17 months of the pandemic in Poland. [CORRESPONDING AUTHOR] ROBERT FLISIAK, PIOTR RZYMSKI, DOROTA ZARĘBSKA-MICHALUK, [AUTH.] MAGDALENA ROGALSKA, MARTA RORAT, PIOTR CZUPRYNA, BEATA LORENC, PRZEMYSŁAW CIECHANOWSKI, DOROTA KOZIELEWICZ, ANNA PIEKARSKA, MARIA POKORSKA-ŚPIEWAK, KATARZYNA SIKORSKA, MAGDALENA TUDRUJEK, BEATA BOLEWSKA, GRZEGORZ ANGIELSKI, JUSTYNA KOWALSKA, REGINA PODLASIN, WŁODZIMIERZ MAZUR, BARBARA OCZKO-GRZESIK, IZABELA ZALESKA, ALEKSANDRA SZYMCZAK, PAULINA FRAŃCZAK-CHMURA, MAŁGORZATA SOBOLEWSKA-PILARCZYK, KRZYSZTOF KŁOS, MAGDALENA FIGLEROWICZ, PIOTR LESZCZYŃSKI, IZABELA KUCHAREK, HUBERT GRABOWSKI. J.Clin.Med. 2022 Vol.11 no.1 art.117 [12 p.],
15. The effect of antiretroviral therapy on SIRT1, SIRT3 and SIRT6 expression in HIV-infected patients. [AUTH.] KAROLINA JURKOWSKA, [CORRESPONDING AUTHOR] BEATA SZYMAŃSKA, [AUTH.] BRYGIDA KNYSZ, AGNIESZKA PIWOWAR. Molecules 2022 Vol.27 no.4 art.1358 [13 p.]
16. Asymptomatic human immunodeficiency virus-1 infection with high CD4+ T cell count does not alter iron metabolism or hepcidin levels: the pilot study. [AUTH.] ALEKSANDRA SZYMCZAK, MAŁGORZATA ZALEWSKA, WERONIKA RYMER, EWA A. JANKOWSKA. Infect.Dis.Ther. 2022 Vol.11 no.1 pp.265-275,
17. Demographic and clinical overview of hospitalized COVID-19 patients during the first 17 months of the pandemic in Poland. [CORRESPONDING AUTHOR] ROBERT FLISIAK, PIOTR RZYMSKI, DOROTA ZARĘBSKA-MICHALUK, [AUTH.] MAGDALENA ROGALSKA, MARTA RORAT, PIOTR CZUPRYNA, BEATA LORENC, PRZEMYSŁAW CIECHANOWSKI, DOROTA KOZIELEWICZ, ANNA PIEKARSKA, MARIA POKORSKA-ŚPIEWAK, KATARZYNA SIKORSKA, MAGDALENA TUDRUJEK, BEATA BOLEWSKA, GRZEGORZ ANGIELSKI, JUSTYNA KOWALSKA, REGINA PODLASIN, WŁODZIMIERZ MAZUR, BARBARA OCZKO-GRZESIK, IZABELA ZALESKA, ALEKSANDRA SZYMCZAK, PAULINA FRAŃCZAK-CHMURA, MAŁGORZATA SOBOLEWSKA-PILARCZYK, KRZYSZTOF KŁOS, MAGDALENA FIGLEROWICZ, PIOTR LESZCZYŃSKI, IZABELA KUCHAREK, HUBERT GRABOWSKI. J.Clin.Med. 2022 Vol.11 no.1 art.117 [12 p.],
18. Differences in expression of selected interleukins in HIV-infected subjects undergoing antiretroviral therapy. [AUTH.] BEATA SZYMAŃSKA, [CORRESPONDING AUTHOR] KAROLINA JURKOWSKA, [AUTH.] BRYGIDA KNYSZ, AGNIESZKA PIWOWAR. Viruses-Basel 2022 Vol.14 no.5 art.997 [14 p.]
19. Effect of combined antiretroviral therapy on the levels of selected parameters reflecting metabolic and inflammatory disturbances in HIV-infected patients. [AUTH.] KAROLINA JURKOWSKA, [CORRESPONDING AUTHOR] BEATA SZYMAŃSKA, [AUTH.] BRYGIDA KNYSZ, AGNIESZKA PIWOWAR. J.Clin.Med. 2022 Vol.11 no.6 art.1713 [14 p.],
20. How humoral response and side effects depend on the type of vaccine and past SARS-CoV-2 infection. [CORRESPONDING AUTHOR] MONIKA STĘPIEŃ, [AUTH.] MAŁGORZATA ZALEWSKA, BRYGIDA KNYSZ, NATALIA ŚWIĄTONIOWSKA-LONC, BEATA JANKOWSKA-POLAŃSKA, ŁUKASZ ŁACZMAŃSKI, AGNIESZKA PIWOWAR, AMADEUSZ KUŹNIARSKI. Vaccines 2022 Vol.10 no.7 art.1042 [16 p.],
21. Inflammatory and thrombotic parameters associated with the COVID-19 course in Poland (SARSTer study). [AUTH.] PIOTR CZUPRYNA, [CORRESPONDING AUTHOR] ANNA MONIUSZKO-MALINOWSKA, [AUTH.] MAGDALENA ROGALSKA, DOROTA ZARĘBSKA-MICHALUK, BEATA LORENC, MARTA RORAT, DOROTA KOZIELEWICZ, MAGDALENA TUDRUJEK-ZDUNEK, KATARZYNA SIKORSKA, ALEKSANDRA BERKAN-KAWIŃSKA, BEATA BOLEWSKA, WŁODZIMIERZ MAZUR, JUSTYNA KOWALSKA, BARBARA OCZKO-GRZESIK, REGINA PODLASIN, ANNA PIEKARSKA, KRZYSZTOF KŁOS, ALEKSANDRA SZYMCZAK, PIOTR LESZCZYŃSKI, KATARZYNA MACIEJEWSKA, SŁAWOMIR PANCEWICZ, JERZY JAROSZEWICZ, ROBERT MILEWSKI, MONIKA GROTH, ROBERT FLISIAK. Adv.Med.Sci. 2022 Vol.67 no.2 pp.291-297
22. The association of airborne particulate matter and benzo[a]pyrene with the clinical course of COVID-19 in patients hospitalized in Poland. [CORRESPONDING AUTHOR] PIOTR RZYMSKI, [AUTH.] BARBARA PONIEDZIAŁEK, JOANNA ROSIŃSKA, MAGDALENA ROGALSKA, DOROTA ZARĘBSKA-MICHALUK, MARTA RORAT, ANNA MONIUSZKO-MALINOWSKA, BEATA LORENC, DOROTA KOZIELEWICZ, ANNA PIEKARSKA, KATARZYNA SIKORSKA, ANNA DWORZAŃSKA, BEATA BOLEWSKA, GRZEGORZ ANGIELSKI, JUSTYNA KOWALSKA, REGINA PODLASIN, BARBARA OCZKO-GRZESIK, WŁODZIMIERZ MAZUR, ALEKSANDRA SZYMCZAK, ROBERT FLISIAK. Environ.Pollut. 2022 Vol.306 art.119469 [9 p.]
23. The effect of antiretroviral therapy on SIRT1, SIRT3 and SIRT6 expression in HIV-infected patients. [AUTH.] KAROLINA JURKOWSKA, [CORRESPONDING AUTHOR] BEATA SZYMAŃSKA, [AUTH.] BRYGIDA KNYSZ, AGNIESZKA PIWOWAR. Molecules 2022 Vol.27 no.4 art.1358 [13 p.],

Contact: Office of the Clinical Department
ul. Koszarowa 5, A3 building, 1st floor
Joanna Musiał, MA
tel.  71 395-75-49
e-mail:  joanna.musial@umw.edu.pl

Assistant Professors for Didactics
Bartosz Szetela, MD, PhD
e-mail: bartosz.szetela@umw.edu.pl Martyna Biała, MD, PhD
e-mail: martyna.biala@umw.edu.pl

Undergraduate training

• classes with 4th and 6th year students of the Medical Faculty of PL and ED, as well as
  3rd year students of Emergency Medical Service of the Faculty of Health Sciences
• elective classes in the Faculty of Medicine (Travel medicine, tropical diseases, vaccination and Prevention of blood-borne infections)
• it has been in operation since 1998. Student Scientific Club. The work prepared by the students has been repeatedly awarded at student club conferences.

Postgraduate training
for selected target groups on infectious diseases

• Course Regulations

Links to the PL and ED Syllabuses

• https://sylabusy.umw.edu.pl/pl
• https://sylabusy.umw.edu.pl/en

Termin egzaminu w roku akademickim 2023/2024
27 czerwca 2024 r., godz. 10:00
Link do Kalendarza egzaminów:

https://www.umw.edu.pl/pl/zarzadzanie-jakoscia-w-obszarze-ksztalcenia/k…