1st Clinical Department of Paediatrics, Allergology and Cardiology

- Epidemiology of allergic diseases and bronchial asthma in children and adults living in rural areas in south-western Poland – the role of environmental factors in the prevention of these conditions.

- Determinants of bacterial airway microbiota in oropharyngeal swabs and exhaled air condensates in the course of bronchial asthma in a paediatric population.

- Arginine and its analogues as new biomarkers determined in serum and exhaled air condensate for the diagnosis and monitoring of bronchial asthma in the paediatric population.

- Assessment of quality of life and selected clinical parameters in allergic rhinitis in children.

- Epigenetic modifications during the prenatal period related to environmental factors and maternal diet in relation to the occurrence of allergic diseases in children.

- SERPING1 gene expression in patients with congenital angioedema.

- Genetics of allergic diseases: research activities in this area aim to understand and explore the role of genetic factors in the pathogenesis of atopic dermatitis and other allergic conditions. The key research topics underway in the field of genetics include:

• Polymorphisms within Toll-like receptors and the CD14 receptor in atopic children.
• Genetic variants within chromosomal regions associated with atopic dermatitis (polymorphisms and mutations in chromosomal region 1q21: FLG, FLG2, SPRP2B, HRNR and polymorphisms located in chromosomal region 11q13) as a prognostic factor for the development of atopic disorders.
• Prognostic significance of polymorphisms of selected atopic dermatitis-associated genes (AP5B1/OVOL1, IL4/KIF3A, ACLT9, COL5A3, MMP9) in the development of allergic march.

- Phenotypes of atopic dermatitis in children - characterisation based on clinical features, genetic factors, biomarkers and degree of response to treatment.

Department's Genetics Laboratory:

Within the Department, there is a Genetics Laboratory conducting genetic research based on the Real-Time PCR method using hybridisation probes.

International and national cooperation:

National Heart and Lung Institute, Imperial College London, United Kingdom

Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

Asthma and Allergy Department of the Dr von Hauner Children’s Hospital, University of Munich, Germany

Laboratory of Genomics and Informatics, Hirszfeld Institute of Immunology and Experimental Therapy of Polish Academy of Sciences, Wrocław

Projects funded under the European Union Framework Programmes

5th European Union Framework Programme: 2002-2004 – Environmental Influences and Infection as Aetiological Agencies in Atopy and Asthma in Young Children, AMICS, project manager Prof. P. Cullinan, Imperial College, London, United Kingdom

6th European Union Framework Programme: 2006-2011 – A multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community GABRIEL, project manager Prof. W. Cookson, Imperial College, London, United Kingdom

6th European Union Framework Programme: 2007-2009 – Forum for Allergy Prevention FORALLVENT – EU FP7, project manager Prof. Erica von Mutius, Ludwig-Maximilians University, Munich, Germany

7th European Union Framework Programme: FP7: 2WAYS Communicating Life Science Research.

National Science Centre grants

OPUS  24: 2023-2027 “Environmental and epigenetic modifications and prevention of atopy and allergic diseases in a rural population of children and adults – 20 years of observations.”  Grant manager: Wroclaw Medical University professor Barbara Sozańska, MD, PhD, project value: PLN 2,507,810.

OPUS 1 : 2011-2014 “Changes in the rural environment and their impact on the prevalence of allergic diseases in rural areas in Poland.” Grant manager: university professor Barbara Sozańska, MD, PhD.

OPUS 9: 2016-2021 “Epigenetic modifications during the fetal period associated with maternal atopy status and diet as a risk factor for IgE-mediated food allergy and wheezing in the child's first year of life, EWAS study.” Grant manager: Hanna Danielewicz, MD, PhD

Thresholds for paediatrics test exam marks after excluding 3 test questions:

Satisfactory grade (3.0) a minimum of 60% correct answers
Fairly good grade (3.5) a minimum of 70% correct answers
Good grade (4.0) a minimum of 80% correct answers
Grade above good (4.5) a minimum of 87% correct answers
Very good grade (5.0) a minimum of 94% correct answers
A failing grade in the test will result in a failing grade for the subject of paediatrics in the first term.