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Division of Immunopathology and Molecular Biology
Department of Human Morphology and Embryology
Division of Immunopathology and Molecular Biology
Wroclaw Medical University
ul. Bujwida 44 50-345 Wrocław
tel: 697-772-029
Head of the Division: Prof. Julia Bar
Prof. Julia Bar
e-mail: julia.bar@umw.edu.pl
tel. 697-770-614
Anna Hanc-Wójcik, MA
e-mail: anna.hanc-wojcik@umw.edu.pl
tel.: 697 773 029
Prof. Michał Jeleń
e-mail: michal.jelen@umw.edu.pl
tel.: 697 772 251
Iwona Deszcz, MD, PhD
e-mail: iwona.deszcz@umw.edu.pl
tel.: 697 772 033
Anna Lis-Nawara, MD, PhD
e-mail: anna.lis-nawara@umw.edu.pl
tel.: 697 772 033
Piotr Grelewski, MD, PhD
e-mail: piotr.grelewski@umw.edu.pl
tel.: 697 772 033
WYDZIAŁ LEKARSKO-STOMATOLOGICZY
Seminaria:
1. Ontogeneza układu immunologicznego.
2. Budowa i właściwości przeciwciał. Nieswoista odpowiedź immunologiczna. Odporność związana z błonami śluzowymi w aspekcie odpowiedzi immunologicznej.
3. Swoista odpowiedź immunologiczna. Nadwrażliwość. Immunologia zakażeń. Szczepionki. Immunomodulacja.
4. Podstawy immunologii transplatacyjnej. Autoimmunizacja i choroby autoimmunologiczne.
5. Pierwotne i wtórne niedobory immunologiczne. Mechanizmy obronne w chorobie nowotworowej.
Tematy ćwiczeń :
1. Rola antygenów w odpowiedzi immunologicznej.
2. Przygotowanie materiału biologicznego do badań immunologicznych.
3. Wykrywanie antygenów w tkankach i komórkach metodą immunofluorescencji.
4. Wykrywanie antygenów w tkankach i komórkach metodą immunohistochemiczną.
5. Test zaliczeniowy.
WYDZIAŁ FARMAUCETYCZNY
Wykłady:
godz. 17:00 on-line
1. 03.10. 2023 Ontogeneza układu immunologicznego.
2. 10.10.2023 Humoralna i komórkowa odpowiedź immunologiczna – czynniki regulujące intensywność odpowiedzi immunologicznej.
3. 17.10.2023 Nadwrażliwość immunologiczna.
4. 24.10.2023 Farmakologiczna regulacja odpowiedzi immunologicznej. Podstawy immunologii transplantacyjnej.
5. 07. 11.2023 Immunologiczne aspekty rozwoju nowotworów – możliwości immunoterapii.
6. 14.11.2023 Farmakologiczna regulacja odpowiedzi immunologicznej.
7. 21.11.2023 Immunodiagnostyka – zastosowanie.
Konsultacje z przedmiotu Immunologia dla studentów
Wydziału Farmaceutycznego
oraz Wydziału Lekarsko-Stomatologicznego.
prof. dr hab. Julia Bar
poniedziałki godz.12.00-13.00
tel. 697-770-614
prof. dr hab. Michał Jeleń
wtorki godz.10.00-11.00
tel. 697 772 251
dr Iwona Deszcz
czwartki godz.11.00-13.00
tel. 697 772 033
ENGLISH DIVISION
IMMUNOLOGY
Topics :
1. Introduction.
2. Development of lymphocytes B. Development and maturation of T lymphocytes.
3. Innate immune response. Adaptive immune response.
4. Defence against infectious agents. Immunomodulation. Vaccination.
5. Hypersensitivities.
6. Transplantation immunological aspects. Immunological tolerance autoimmunity
and autoimmune diseases.
7. Primary and secondary deficiencies. Immunity to cancer and immunomodulation.
Laboratory :
1. The role of antigens.
2. Biological materials.
3. Immunofluorescence.
4. Immunohistochemistry.
5. Estimation under microscope.
6. Usefulness of antigens in immunological diagnosis.
TEST of 30 single-choice questions.
To pass the test the student must receive 21 points.
-
The exam in Immunology will take place on 14 June 2023 at
12:00 noon.
10. Full-value antigens, haptens.
11. Structure of antibodies, classes and subclasses, affinity, valency.
12. Types of antibodies (humoral, polyclonal, monoclonal).
13. Participation of antibodies in the immune response.
14. Non-specific immune response, complement system, phagocytosis.
15. The role of interferons in the immune response. Opportunities for use in therapy.
16. The role of NK cells, granulocytes, macrophages in immunity.
17. Immunity associated with mucous membranes and skin.
18. The role of cytokines in the immune response, types of cytokines - the mechanism of action.
19. Mechanisms involved in the immune response: cell type response - role of Th1 and Tc lymphocytes.
20. Humoral type responses to antigens: thymus-dependent, thymus-independent, the role of Th2 lymphocytes in the immune response. .
21. T and B cell cooperation, the role of APCs, the mechanism of foreign antigen recognition, MHC class I and II restriction.
22. Antibody-dependent cellular cytotoxicity (ADCC) – reaction stages. Cells involved in the reaction.
23. Types of hypersensitivity reactions - pathomechanism, involvement of cellular and humoral factors, mediators of the inflammatory process in allergies.
24. Allergic diseases - treatment options.
25. Innate and acquired immunological tolerance, breaking tolerance. Autoimmunisation. Immune-related diseases.
26. Immunomodulation – the role of drugs.
27. Therapeutic application of immunomodulation.
28. Types of immune system modulators - examples of action.
29. Pharmacological immunosuppression - clinical relevance.
30. Immunological mechanisms of organ transplantation, host-versus-graft responses; graft - versus - host.
31. The role of MHC molecules, macrophages and subpopulations of T and B lymphocytes, APC cells in antigen presentation in the organ recipient.
32. Types of vaccines and the type of immune response. Anti-idiotypic antibodies as vaccines.
33. Modern concepts on cancer development, the role of tumour suppressor genes and oncogenes in cancer development.
34. The role of viruses in the development of cancer.
35. Immunodiagnostic possibilities of the cancer process.
36. The importance of antigens in the treatment and prognosis of cancer and autoimmune diseases.
37. Immune response to tumour-associated antigens. Circulating antigens and the immune response.
38. Suppression of the immune response, counter-suppression, mechanisms of anti-tumour immunity.
39. Immunological mechanisms facilitating tumour growth.
40. The importance of circulating markers, marking techniques, possibilities of practical use of markers.
41. Specific and non-specific mechanisms of anti-infective immunity.
42. Type of pathogen and immune response.
43. Mechanisms facilitating the development of pathogenic infections.
44. The opportunities to apply scientific advances in immunology to clinical practice.
45. Immune tolerance and organ transplantation. Immunological aspects of transplantation,
46. Autoimmune diseases, examples.
47. Immunological aspects of organ-specific diseases.
48. Specific and non-specific immunotherapy.
49. Inflammation as an immunological process
50. Immunological aspects of the inflammation process.
51. Dysfunction of the immune response in primary and secondary immune deficiencies
Textbooks:
1. Gołąb, J., Jakóbisiak, M, Lasek, W, Stokłosa T. Immunologia 2007
2. W. Lasek. Immunologia. Podstawowe zagadnienia i aktualności - 2005
3. D. Male, J.Brostoff, D.B. Roth, I. Roitt "Immunology”, 2007
Chemical properties of the antigen, immunogenicity, antigenicity.
Types of antigens, antigen-antibody reactions.
Subpopulations of T- and B-lymphocytes, phenotype, participation in the immune response.
Surface markers.
Selection of T and B lymphocytes.
Immune system cells: maturation of T and B lymphocytes, APCs, NK cells.
Structure of the thymus; role of the blood-thymus barrier.
The role of primary and secondary lymphatic organs.
Ontogenesis, basic components of the immune system.
Mandatory topics for the exam in Immunology:
Publikacje Zakładu Immunopatologii i Biologii Molekularnej:
BAR JK, Lis-Nawara A, Kowalczyk T, Grelewski PG, Stamnitz S, Gerber H, Klimczak A. Int J Mol Sci. 2023 Nov 25;24(23):16747. doi: 10.3390/ijms242316747.
The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma.
Cierpikowski P, Leszczyszyn A, Bar J. Cells. 2023 Aug 17;12(16):2083. doi: 10.3390/cells12162083.
Properties of scaffolds as carriers of mesenchymal stem cells for use in bone engineering.
GRELEWSKI PG, Kwaśnicka M, Bar JK. Polim Med. 2023 Jul-Dec;53(2):129-139. doi: 10.17219/pim/166471.
Prognostic Value of WNT1, NOTCH1, PDGFRβ, and CXCR4 in Oral Squamous Cell Carcinoma.
Cierpikowski P, Lis-Nawara A, Bar J. Anticancer Res. 2023 Feb;43(2):591-602. doi: 10.21873/anticanres.16195.
Comparison of biomarker expression in oral lichen planus and oral lichenoid lesions.
Radwan-Oczko M, Lis-Nawara A, Hałoń A, Bar J. Adv Clin Exp Med. 2022 Dec;31(12):1327-1334. doi: 10.17219/acem/152429.
Advances in Electrospun Hybrid Nanofibers for Biomedical Applications.
Nirwan VP, Kowalczyk T, Bar J, Buzgo M, Filová E, Fahmi A. Nanomaterials (Basel). 2022 May 27;12(11):1829. doi: 10.3390/nano12111829.
BAR JK, Kowalczyk T, Grelewski PG, Stamnitz S, Paprocka M, Lis J, Lis-Nawara A, An S, Klimczak A. Materials (Basel). 2022 Mar 3;15(5):1900. doi: 10.3390/ma15051900.
Organization of the 43rd European Congress of Cytology in the SARS-CoV-2 pandemic period: A report.
Klijanienko J, Cochand-Priollet B, Król-Cieciorowska W, Jeleń M, Vrdoljak-Mozetič D.Cancer Cytopathol. 2022 Jul;130(7):488-490. doi: 10.1002/cncy.22578. Epub 2022 Apr 13.
Comparison of p53, HSP90, E-cadherin and HPV in oral lichen planus and oral squamous cell carcinoma.
BAR JK, Cierpikowski P, Lis-Nawara A, Duc P, Hałoń A, Radwan-Oczko M. Acta Otorhinolaryngol Ital. 2021 Dec;41(6):514-522. doi: 10.14639/0392-100X-N1450.
Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential.
BAR JK, Lis-Nawara A, Grelewski PG. Int J Mol Sci. 2021 Nov 6;22(21):12018. doi: 10.3390/ijms222112018.
Cierpikowski P, Lis-Nawara A, Bar J. Anticancer Res. 2021 Nov;41(11):5405-5413. doi: 10.21873/anticanres.15352.
Sonic Hedgehog is a novel prognostic biomarker in patients with oral squamous cell carcinoma.
Cierpikowski P, Lis-Nawara A, Bar J. Neoplasma. 2021 Jul;68(4):867-874. doi: 10.4149/neo_2021_201204N1304. Epub 2021 May 17.
DESZCZ I, Lis-Nawara A, Grelewski P, Dragan S, Bar J. Regen Biomater. 2020 Aug 23;7(6):543-552. doi: 10.1093/rb/rbaa026. eCollection 2020 Dec.
ARID1A/BAF250a is significantly overexpressed in primary invasive breast cancer.
Szpon Ł, Agrawal A, Jelen M, Lipinski A, Rudnicki J, Makuch S, Woźniak M, Szmit M, Agrawal S. Transl Cancer Res. 2020 Jun;9(6):3937-3945. doi: 10.21037/tcr-19-2422.