Foto wizytówka.jpg

dr hab. n. med. Jan Biegus

adiunkt, z-ca dyrektora ds. naukowych

telefon: 71 736 42 05


adres: Uniwersytecki Szpital Kliniczny 
            Instytut Chorób Serca
            ul. Borowska 213, 50-556 Wrocław 

30.01.2020 – PhD in Medicine “The role of biomarkers in pathophysiology of organ dysfunction/injury in acute heart failure.”

14.01.2016 - MD in Medicine on the basis of a doctoral thesis: “Liver dysfunction in acute heart failure. Incidence, pathophysiology and clinical implications”. Wroclaw Medical University –Faculty of Public Health. Supervisor: Professor Piotr Ponikowski

2008-2014 - specialization in cardiology, Łódź, Poland

2005- 2006 internship in 4th Clinical Military Hospital Wroclaw

1999-2005 - Wroclaw Medical University (at that time Wroclaw Medical Academy)– Faculty of Medicine

Form 2021 – present: deputy of scientific director in Institute of Heart Diseases, Wroclaw Medical University

From 2021 – present: Senior Lecturer, Institute of Heart Diseases, Wroclaw Medical University

2021- Senior Assistant at the Intensive Cardiological Care Unit at the Institute of Heart Diseases, University Clinical Hospital, Wrocław

2017 - 2021 Senior Lecturer, Department of Heart Disease, Wroclaw Medical University

2019- 2021 Senior Assistant at the Intensive Cardiological Care Unit at the Department of Cardiology in Center of Heart Diseases, University Clinical Hospital, Wrocław

2012-2019 Senior Assistant at the Intensive Cardiological Care Unit at the Department of Cardiology in Heart Disease Centre in the 4th Military Teaching Hospital in Wroclaw

2006-2019 Assistant and Senior Assistant, Department of Cardiology, Centre of Heart Disease, 4th Clinical Military Hospital, Wroclaw, Poland

2006-2009 Physician in Emergency Medicine

  • The Special Award form Polish Heart Association 2021
  • The scholarship from Ministry of Education and Science for the distinguished, young scientist in Poland 2021
  • The 1st degree Award of the Rector of Medical University Wroclaw for a publication in 2018, 2019,2020, 2021
  • The 1st degree Award of the Rector of Medical University Wroclaw for a series of publications in 2017
  • The 1st degree Award of Polish Society of Internal Medicine for the best original paper in 2012
  • Best (HOT -heart failure socialist of tomorrow) European Journal of Heart Failure Reviewer 2015

Active reviewer of:

  • Polish Heart Journal
  • European Journal of Heart Failure, I won best HOT (Heart failure specialist Of Tomorrow) reviewer of EJHF award in 2015
  • European Heart Journal
  • Polish Archives of Internal Diseases
  • Journal of Cardiac Failure
  • 2015-2017–co-author and an executor of the grant no. 905 titled: ”Discharge mulimarker assessment model for acute heart failure patients for risk stratification.”
  • 2011-2014 – an executor of the project MNII Nr NN 519 654340 titled “Computer based analysis system of clinical and biomarkers variables for short and long term prognosis in patients with acute heart failure”
  • European Society of Cardiology (ESC)
  • HFA (Heart Failure Association of the ESC)
  • ACCA (Acute Cardiac Care Association of the ESC)
  • Polish Cardiac Society
  • ​​​​​​ Since 2015 I have been the Head the Cardiology specialization of the one resident
  • Since 2017 I have been employed as an academic teacher as an assistant. I have conducted clinical practical classes and lectures for the students at the Faculty of Health Sciences and Faculty of Medicine (Polish- and English language studies) at Wroclaw Medical University
  • I am certified instructor of Advanced Life Support courses by European Resuscitation Council– thus I trained physicians/medical students/emergency department fellows/nurses in many Advanced Life Support courses
  • I was a mentor during Cardiology Innovation Days Conference, Wroclaw, 2018 and 2019

The most important papers (H-index –20):

1. Biegus J, Voors AA, Collins SP, et al. Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial. Eur Heart J 2023;44:41-50. doi: 10.1093/eurheartj/ehac530

2. Zymlinski R, Dierckx R, Biegus J, et al. Novel IVC Doraya Catheter Provides Congestion Relief in Patients With Acute Heart Failure. JACC Basic Transl Sci 2022;7:326-327. doi: 10.1016/j.jacbts.2022.02.013

3. Zdanowicz A, Urban S, Ponikowska B, et al. Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure. J Pers Med 2022;12. doi: 10.3390/jpm12060898

4. Voors AA, Damman K, Teerlink JR, et al. Renal effects of empagliflozin in patients hospitalized for acute heart failure: from the EMPULSE trial. Eur J Heart Fail 2022;24:1844-1852. doi: 10.1002/ejhf.2681

5. Voors AA, Angermann CE, Teerlink JR, et al. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial. Nat Med 2022;28:568-574. doi: 10.1038/s41591-021-01659-1

6. Urban S, Horozaniecka P, Wlodarczak S, et al. Tablet-Based Assessment of Cognitive Function Among Heart Failure Patients. Crit Pathw Cardiol 2022;21:147-152. doi: 10.1097/HPC.0000000000000291

7. Urban S, Fulek M, Blaziak M, et al. COVID-19 Related Myocarditis in Adults: A Systematic Review of Case Reports. J Clin Med 2022;11. doi: 10.3390/jcm11195519

8. Urban S, Blaziak M, Jura M, et al. Novel Phenotyping for Acute Heart Failure-Unsupervised Machine Learning-Based Approach. Biomedicines 2022;10. doi: 10.3390/biomedicines10071514

9. Urban S, Blaziak M, Jura M, et al. Machine Learning Approach to Understand Worsening Renal Function in Acute Heart Failure. Biomolecules 2022;12. doi: 10.3390/biom12111616

10. Ponikowska B, Iwanek G, Zdanowicz A, et al. Biomarkers of Myocardial Injury and Remodeling in Heart Failure. J Pers Med 2022;12. doi: 10.3390/jpm12050799

11. Piepoli MF, Adamo M, Barison A, et al. Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology. Eur J Heart Fail 2022;24:143-168. doi: 10.1002/ejhf.2351

12. Nunez J, de la Espriella R, Rossignol P, et al. Congestion in heart failure: a circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology. Eur J Heart Fail 2022;24:1751-1766. doi: 10.1002/ejhf.2664

13. Minhas AMK, Bhopalwala HM, Dewaswala N, et al. Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction. Curr Probl Cardiol 2022:101199. doi: 10.1016/j.cpcardiol.2022.101199

14. Lagosz P, Sokolski M, Biegus J, Tycinska A, Zymlinski R. Elevated intra-abdominal pressure: A review of current knowledge. World J Clin Cases 2022;10:3005-3013. doi: 10.12998/wjcc.v10.i10.3005

15. Lagosz P, Biegus J, Gruszka E, Zymlinski R. The surprising course of multiple sclerosis relapse in a patient after SARS-CoV-2 vaccination. Kardiol Pol 2022;80:237-238. doi: 10.33963/KP.a2022.0005

16. Kosiorek A, Biegus J, Rozentryt P, Hurkacz M, Zymlinski R. Cardiorenal syndrome: Decongestion in heart failure across wide spectrum of kidney pathophysiology. Adv Clin Exp Med 2022;31:445-455. doi: 10.17219/acem/144327

17. Kosiborod MN, Angermann CE, Collins SP, et al. Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial. Circulation 2022;146:279-288. doi: 10.1161/CIRCULATIONAHA.122.059725

18. Guzik M, Urban S, Iwanek G, et al. Novel Therapeutic Devices in Heart Failure. J Clin Med 2022;11. doi: 10.3390/jcm11154303

19. Guzik M, Sokolski M, Hurkacz M, et al. Serum Osmolarity and Vasopressin Concentration in Acute Heart Failure-Influence on Clinical Course and Outcome. Biomedicines 2022;10. doi: 10.3390/biomedicines10082034

20. Garus M, Zdanowicz A, Fudim M, et al. Clinical determinants and prognostic significance of hypocapnia in acute heart failure. Sci Rep 2022;12:16889. doi: 10.1038/s41598-022-20525-9

21. Gajewski P, Fudim M, Kittipibul V, et al. Early Hemodynamic Changes following Surgical Ablation of the Right Greater Splanchnic Nerve for the Treatment of Heart Failure with Preserved Ejection Fraction. J Clin Med 2022;11. doi: 10.3390/jcm11041063

22. Blaziak M, Urban S, Wietrzyk W, et al. An Artificial Intelligence Approach to Guiding the Management of Heart Failure Patients Using Predictive Models: A Systematic Review. Biomedicines 2022;10. doi: 10.3390/biomedicines10092188

23. Zymlinski R, Biegus J, Ponikowski P. Not all fluid overloads are the same: some practical considerations for better decongestion. Eur J Heart Fail 2021;23:1106-1109. doi: 10.1002/ejhf.2187

24. Urban S, Blaziak M, Biegus J, Zymlinski R. Ultrafiltration in acute heart failure: Current knowledge and fields for further research. Adv Clin Exp Med 2021;30:737-746. doi: 10.17219/acem/135347

25. Tycinska A, Grygier M, Biegus J, et al. Mechanical circulatory support. An expert opinion of the Association of Intensive Cardiac Care and the Association of Cardiovascular Interventions of the Polish Cardiac Society. Kardiol Pol 2021;79:1399-1410. doi: 10.33963/KP.a2021.0169

26. Tromp J, Ponikowski P, Salsali A, et al. Sodium-glucose co-transporter 2 inhibition in patients hospitalized for acute decompensated heart failure: rationale for and design of the EMPULSE trial. Eur J Heart Fail 2021;23:826-834. doi: 10.1002/ejhf.2137

27. Sokolski M, Gajewski P, Zymlinski R, et al. Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across Europe. Am J Med 2021;134:482-489. doi: 10.1016/j.amjmed.2020.08.043

28. Nawrocka-Millward S, Biegus J, Hurkacz M, et al. Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure. Biomolecules 2021;11. doi: 10.3390/biom11111701

29. Malek F, Gajewski P, Zymlinski R, et al. Surgical ablation of the right greater splanchnic nerve for the treatment of heart failure with preserved ejection fraction: first-in-human clinical trial. Eur J Heart Fail 2021;23:1134-1143. doi: 10.1002/ejhf.2209

30. Cox ZL, Rao VS, Ivey-Miranda JB, et al. Compensatory post-diuretic renal sodium reabsorption is not a dominant mechanism of diuretic resistance in acute heart failure. Eur Heart J 2021;42:4468-4477. doi: 10.1093/eurheartj/ehab620

31. Biegus J, Zymlinski R, Testani J, et al. Renal profiling based on estimated glomerular filtration rate and spot urine sodium identifies high-risk acute heart failure patients. Eur J Heart Fail 2021;23:729-739. doi: 10.1002/ejhf.2053

32. Biegus J, Zymlinski R, Fudim M, et al. Spot urine sodium in acute heart failure: differences in prognostic value on admission and discharge. ESC Heart Fail 2021;8:2597-2602. doi: 10.1002/ehf2.13372

33. Biegus J, Niewinski P, Josiak K, et al. Pathophysiology of Advanced Heart Failure: What Knowledge Is Needed for Clinical Management? Heart Fail Clin 2021;17:519-531. doi: 10.1016/j.hfc.2021.06.001

34. Biegus J, Nawrocka-Millward S, Zymlinski R, et al. Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure. Int J Cardiol 2021;345:54-60. doi: 10.1016/j.ijcard.2021.10.149

35. Zymlinski R, Sierpinski R, Metra M, et al. Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure. ESC Heart Fail 2020;7:3536-3544. doi: 10.1002/ehf2.13064

36. Zymlinski R, Ponikowski P, Biegus J. Looking at the heart failure through the prism of liver dysfunction. Eur J Heart Fail 2020;22:1672-1674. doi: 10.1002/ejhf.1932

37. Sokolska JM, Sokolski M, Zymlinski R, et al. Distinct clinical phenotypes of congestion in acute heart failure: characteristics, treatment response, and outcomes. ESC Heart Fail 2020;7:3830-3840. doi: 10.1002/ehf2.12973

38. Zymlinski R, Sokolski M, Biegus J, et al. Multi-organ dysfunction/injury on admission identifies acute heart failure patients at high risk of poor outcome. Eur J Heart Fail 2019;21:744-750. doi: 10.1002/ejhf.1378

39. Sokolski M, Zymlinski R, Sokolska JM, et al. True worsening renal function identifies patients with acute heart failure with an ominous outcome. Pol Arch Intern Med 2019;129:357-360. doi: 10.20452/pamw.4453

40. Sokolska JM, Sokolski M, Zymlinski R, et al. Patterns of dyspnoea onset in patients with acute heart failure: clinical and prognostic implications. ESC Heart Fail 2019;6:16-26. doi: 10.1002/ehf2.12371

41. Ponikowska M, Biegus J, Zymlinski R, Szepietowski JC. Itch in Patients with Acute Heart Failure. Acta Derm Venereol 2019;99:679-680. doi: 10.2340/00015555-3187

42. Biegus J, Zymlinski R, Sokolski M, et al. Serial assessment of spot urine sodium predicts effectiveness of decongestion and outcome in patients with acute heart failure. Eur J Heart Fail 2019;21:624-633. doi: 10.1002/ejhf.1428

43. Biegus J, Zymlinski R, Sokolski M, et al. Elevated lactate in acute heart failure patients with intracellular iron deficiency as identifier of poor outcome. Kardiol Pol 2019;77:347-354. doi: 10.5603/KP.a2019.0014

44. Biegus J, Zymlinski R, Sokolski M, et al. Clinical, respiratory, haemodynamic, and metabolic determinants of lactate in heart failure. Kardiol Pol 2019;77:47-52. doi: 10.5603/KP.a2018.0240

45. Biegus J, Zymlinski R, Siwolowski P, et al. Controlled decongestion by Reprieve therapy in acute heart failure: results of the TARGET-1 and TARGET-2 studies. Eur J Heart Fail 2019;21:1079-1087. doi: 10.1002/ejhf.1533

46. Biegus J, Zymlinski R, Gajewski P, et al. Persistent hyperlactataemia is related to high rates of in-hospital adverse events and poor outcome in acute heart failure. Kardiol Pol 2019;77:355-362. doi: 10.5603/KP.a2019.0030

47. Biegus J, Demissei B, Postmus D, et al. Hepatorenal dysfunction identifies high-risk patients with acute heart failure: insights from the RELAX-AHF trial. ESC Heart Fail 2019;6:1188-1198. doi: 10.1002/ehf2.12477

48. Zymlinski R, Biegus J, Sokolski M, et al. Increased blood lactate is prevalent and identifies poor prognosis in patients with acute heart failure without overt peripheral hypoperfusion. Eur J Heart Fail 2018;20:1011-1018. doi: 10.1002/ejhf.1156

49. Zymlinski R, Biegus J, Sokolski M, et al. Validation of transurethral intraabdominal pressure measurement in acute heart failure. Pol Arch Intern Med 2018;128:403-405. doi: 10.20452/pamw.4290

50. Zymlinski R, Sokolski M, Siwolowski P, et al. Elevated troponin I level assessed by a new high-sensitive assay and the risk of poor outcomes in patients with acute heart failure. Int J Cardiol 2017;230:646-652. doi: 10.1016/j.ijcard.2017.01.012

51. Sokolski M, Zymlinski R, Biegus J, et al. Urinary levels of novel kidney biomarkers and risk of true worsening renal function and mortality in patients with acute heart failure. Eur J Heart Fail 2017;19:760-767. doi: 10.1002/ejhf.746

52. Kosowski M, Kubler P, Kolodziej A, et al. InterAtrial Shunt Device (IASD(R)) implantation - a novel treatment method for heart failure with preserved ejection fraction. Kardiol Pol 2017;75:736-741. doi: 10.5603/KP.a2017.0096

53. Biegus J, Zymlinski R, Sokolski M, et al. Impaired hepato-renal function defined by the MELD XI score as prognosticator in acute heart failure. Eur J Heart Fail 2016;18:1518-1521. doi: 10.1002/ejhf.644

54. Biegus J, Hillege HL, Postmus D, et al. Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study. Eur J Heart Fail 2016;18:830-839. doi: 10.1002/ejhf.532

55. Jankowska EA, Kasztura M, Sokolski M, et al. Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. Eur Heart J 2014;35:2468-2476. doi: 10.1093/eurheartj/ehu235

56. Biegus J, Zymlinski R, Sokolski M, et al. Liver function tests in patients with acute heart failure. Pol Arch Med Wewn 2012;122:471-479. doi: 10.20452/pamw.1413

57. Sokolski M, Rydlewska A, Krakowiak B, et al. Comparison of invasive and non-invasive measurements of haemodynamic parameters in patients with advanced heart failure. J Cardiovasc Med (Hagerstown) 2011;12:773-778. doi: 10.2459/JCM.0b013e32834cfebb

58. Josiak K, Inorowicz E, Petruk-Kowalczyk J, et al. [Effect of sildenafil on haemodynamic parameters of pulmonary circulation and physical capacity in patients with systolic chronic heart failure with secondary severe pulmonary hypertension]. Kardiol Pol 2011;69:517-519. doi:

59. Biegus J, Zymlinski R, Szachniewicz J, et al. Clinical characteristics and predictors of in-hospital mortality in 270 consecutive patients hospitalised due to acute heart failure in a single cardiology centre during one year. Kardiol Pol 2011;69:997-1005. doi:

60. Biegus J, Ponikowski P. [Cardio-renal syndrome in patients with heart failure: pathophysiology, epidemiology and clinical significance]. Kardiol Pol 2011;69:1181-1188. doi:

61. Skora J, Biegus J, Pupka A, et al. [Molecular basics of angiogenesis]. Postepy Hig Med Dosw (Online) 2006;60:410-415. doi: