Department of Toxicology

ul. Borowska 211, 50-556 Wrocław
tel.: 71 784 04 51, fax: 71 784 04 52
e-mail: wf-15@umw.edu.pl

Head of the Department

Prof. Agnieszka Piwowar, PhD
e-mail: agnieszka.piwowar@umw.edu.pl

Office

Beata Koprowska
independent administrator
e-mail: beata.koprowska@umw.edu.pl
tel.: 71 784 04 51

Assistant Professors

Anna Bizoń, PhD
e-mail: anna.bizon@umw.edu.pl
tel.: 71 784 04 55

Adriana Kubis-Kubiak, PhD
e-mail: adriana.kubis-kubiak@umw.edu.pl
tel.: 71 784 01 30

Anna Rorbach-Dolata, PhD (maternity leave)
e-mail: anna.rorbach-dolata@umw.edu.pl
tel.: 71 784 01 30

Ewa Sawicka, PhD
e-mail: ewa.sawicka@umw.edu.pl
tel.: 71 784 04 53

Beata Szymańska, PhD
e-mail: beata.szymanska@umw.edu.pl
tel.: 71 784 04 57

Ewa Żurawska-Płaksej, PhD
e-mail: ewa.zurawska-plaksej@umw.edu.pl
tel.: 71 784 04 56

Engineering and technical employees

Anna Basara, MA (maternity leave)
e-mail: anna.basara@umw.edu.pl
tel.: 71 784 04 54

Justyna Michalska, BSc
e-mail: justyna.michalska@umw.edu.pl
tel.:71 784 04 54

Kinga Hupało, MA
e-mail: kinga.hupalo@umw.edu.pl
tel. 71 784 04 54

Natalia Gach, MA
e-mail: natalia.gach@umw.edu.pl
tel. 71 784 04 54

Doctoral School

Kamila Boszkiewicz, MA
e-mail: kamila.boszkiewicz@student.umw.edu.pl
tel.: 71 784 04 51

Katarzyna Lipke, MA
e-mail: katarzyna.lipke@student.umw.edu.pl
tel.: 71 784 04 51

Justyna Niepsuj, MA
e-mail: justyna.niepsuj@student.umw.edu.pl
tel.: 71 784 04 51

Urinary Tract Impairment Markers Laboratory
Head
Beata Szymańska, PhD
e-mail: beata.szymanska@umw.edu.pl
tel.: 71 784 04 57

Toxicological Prevention and Chemical Carcinogenesis Laboratory
Head
Ewa Sawicka, PhD
e-mail: ewa.sawicka@umw.edu.pl
tel.: 71 784 04 53

Molecular Toxicology Laboratory
Head
Adriana Kubis-Kubiak, PhD
e-mail: adriana.kubis-kubiak@umw.edu.pl
tel.: 71 784 01 30

Main research areas:

Assessment of metabolic and hormonal disorders in women with polycystic ovary syndrome and their correlation with exposure to environmental factors, with particular emphasis on endocrine-active compounds;
Estimation of the severity of oxidative stress and inflammation and their impact on the magnitude of neuroinflammatory and demyelinating process disorders in patients with relapsing-remitting multiple sclerosis;
Assessment of the combined effect of estrogens and environmental xenoestrogens in the pathogenesis of hormone-dependent cancers, especially breast cancer and ovarian cancer;
Assessment of the effects of selected xenoestrogens and hyperglycaemia on aromatase inhibitor activity in in vitro breast cancer model studies;
Assessment of the effect of lipotoxicity and selected drugs from the group of nucleoside reverse transcriptase inhibitors on the metabolism of fats and insulin in the cells of the nervous system;
Model studies of signaling pathways in neurotoxicity and excitotoxicity induced by selected chemical agents;
Modeling of neuropathological disorders in the vessel - generation and characterisation of brain organoids and assembloids with different regional identities;
Development and optimisation of an effective method of isolation and culture of neuronal and astrocytic cells obtained from frozen animal material;
Assessment of the effect of antiretroviral therapy on the development of comorbidities and disorders in people with HIV subjected to long-term antiretroviral therapy;
Assessment and evaluation of the diagnostic and prognostic usefulness of selected parameters
in the diagnosis of urinary tract diseases (especially bladder);
The effect of protein glycation (especially albumin) on the binding of drugs most commonly used in the treatment of civilisation diseases based on multi-spectroscopic in vitro studies;
Assessment of the correlation between intestinal microbiota metabolites (trimethylamine N-oxide, p-cresol and indoxyl) and the clinical manifestation of cardiovascular diseases;
Development and validation of methods for the determination of L-arginine metabolites using the LC-MS technique and evaluation of its use in patients with myocardial infarction;
Untargeted Metabolomic Analysis as a tool in the diagnosis and monitoring of various disease entities.
Assessment of the participation of selected xenobiotics in redox imbalance in people exposed to the environment and assessment of predictors of those disorders;
Assessment of glucotoxicity and prooxidative potential of selected xenobiotics based on selected markers of those processes in in vivo and ex vivo studies and assessment of the protective effect of some compounds of natural origin.

Jurkowska K, Szymańska B, Knysz B, Piwowar A. The Effect of Antiretroviral Therapy on SIRT1, SIRT3 and SIRT6 Expression in HIV-Infected Patients. Molecules. 17 February 2022 ;27(4):1358. doi:10.3390/molecules27041358. IF: 4,412 MNiSW: 140,00
Żurawska-Płaksej E, Wiglusz R, Piwowar A, Wiglusz K. In Vitro Investigation of Binding Interactions between Albumin-Gliclazide Model and Typical Hypotensive Drugs. Int J Mol Sci. 28 December 2021 ;23(1):286. doi:10.3390/ijms23010286. IF: 5,924 MNiSW: 140,00
Sawicka E, Saczko J, Kulbacka J, Szydełko M, Szymańska B, Piwowar A. The Influence of Interaction between Cadmium with 17β-Estradiol, 2-Methoxyestradiol and 16α-Hydroxyestrone on Viability and p-Glycoprotein in Ovarian Cancer Cell Line. Int J Mol Sci. 27 February 2022 ;23(5):2628. doi:10.3390/ijms23052628. IF: 5,924 MNiSW: 140,00
Szymańska B, Jurkowska K, Knysz B, Piwowar A. Differences in Expression of Selected Interleukins in HIV-Infected Subjects Undergoing Antiretroviral Therapy. Viruses 2022, 14, 997. doi:10.3390/v14050997 IF: 5,048 MNiSW: 100,00
Lipke K, Kubis-Kubiak A, Piwowar A. Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States-Current View of Knowledge. Cells. 1 March 2022 ;11(5):844. doi:10.3390/cells11050844. IF: 6,600 MNiSW: 140,00
Jankowska-Polańska B, Sarzyńska K, Czwojdziński E, Świątoniowska-Lonc N, Dudek K, Piwowar A. Attitude of Health Care Workers and Medical Students towards Vaccination against COVID-19. Vaccines (Basel). 29 March 2022;10(4):535. doi:10.3390/vaccines10040535. IF: 4,422 MNiSW: 140,00
Jurkowska K, Szymańska B, Knysz B, Piwowar A. Effect of Combined Antiretroviral Therapy on the Levels of Selected Parameters Reflecting Metabolic and Inflammatory Disturbances in HIV-Infected Patients. J Clin Med. 19 March 2022;11(6):1713. doi:10.3390/jcm11061713. IF: 4,242 MNiSW: 140,00
Bizoń A, Tchórz A, Madej P, Leśniewski M, Wójtowicz M, Piwowar A, Franik G. The activity of superoxide dismutase, its relationship with the concentration of zinc and copper and the prevalence of rs2070424 superoxide dismutase gene in women with polycystic ovary syndrome - preliminary study. J Clin Med 2022 Vol.11 no.9 art.2548 [10 p.], doi:10.3390/jcm11092548. IF: 4,242 MNiSW: 140,00
Wiatrak B, Jawień P, Matuszewska A, Szeląg A, Kubis-Kubiak A. Effect of amyloid-β on the redox system activity in SH-SY5Y cells preincubated with lipopolysaccharide or co-cultured with microglia cells. Biomed Pharmacother. May 2022;149:112880. doi:10.1016/j.biopha.2022.112880. IF: 6,530 MNiSW: 100,00
Płaczkowska S, Pawlik-Sobecka L, Kokot I, Piwowar A. The association between serum uric acid and features of metabolic disturbances in young adults. Arch Med Sci. 12 March 2020;17(5):1277-1285. doi:10.5114/aoms.2020.93653. IF: 3,318 MNiSW: 100,00
Wiglusz K, Żurawska-Płaksej E, Rorbach-Dolata A, Piwowar A. How Does Glycation Affect Binding Parameters of the Albumin-Gliclazide System in the Presence of Drugs Commonly Used in Diabetes? In Vitro Spectroscopic Study. Molecules. 24 June 2021;26(13):3869. doi:10.3390/molecules26133869. IF: 4,412 MNiSW: 140,00
Kubis-Kubiak A, Wiatrak B, Piwowar A. The Impact of High Glucose or Insulin Exposure on S100B Protein Levels, Oxidative and Nitrosative Stress and DNA Damage in Neuron-Like Cells. Int J Mol Sci. 24 May 2021;22(11):5526. doi:10.3390/ijms22115526. IF: 5,924 MNiSW: 140,00
Kratz EM, Sołkiewicz K, Kubis-Kubiak A, Piwowar A. Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators. Int J Mol Sci. 10 January 2021;22(2):630. doi:10.3390/ijms22020630. IF: 5,924 MNiSW: 140,00
Kokot I, Piwowar A, Jędryka M, Sołkiewicz K, Kratz EM. Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis. Int J Mol Sci. 25 February 2021;22(5):2295. 2021 Feb 25;22(5):2295. IF: 5,924 MNiSW: 140,00
Bizoń A, Płaczkowska S, Niepsuj J, Czwojdzińska M, Leśniewski M, Nowak A, Pluta D, Madej P, Piwowar A, Franik G. Body Composition and Its Impact on the Hormonal Disturbances in Women with Polycystic Ovary Syndrome. Nutrients. 24 November 2021;13(12):4217. doi:10.3390/nu13124217. IF: 5,719 MNiSW: 140,00
Jurkowska K, Szymańska B, Knysz B, Kuźniarski A, Piwowar A. Sirtuins as Interesting Players in the Course of HIV Infection and Comorbidities. Cells. 13 October 2021;10(10):2739. doi:10.3390/cells10102739. IF: 6,600 MNiSW: 140,00
Kratz EM, Kokot I, Dymicka-Piekarska V, Piwowar A. Sirtuins-The New Important Players in Women's Gynecological Health. Antioxidants (Basel). 10 January 2021;10(1):84. doi:10.3390/antiox10010084. IF: 6,313 MNiSW: 100,00
Kokot I, Piwowar A, Jędryka M, Kratz EM. Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis? Antioxidants (Basel). 8 July 2021;10(7):1097. doi:10.3390/antiox10071097. IF: 6,313 MNiSW: 100,00
Bizoń A, Franik G, Niepsuj J, Czwojdzińska M, Leśniewski M, Nowak A, Szynkaruk-Matusiak M, Madej P, Piwowar A. The Associations between Sex Hormones and Lipid Profiles in Serum of Women with Different Phenotypes of Polycystic Ovary Syndrome. J Clin Med. 31 August 2021;10(17):3941. doi:10.3390/jcm10173941. IF: 4,242 MNiSW: 140,00
Szymańska B, Matuszewski M, Dembowski J, Piwowar A. Initial Evaluation of Uroplakins UPIIIa and UPII in Selected Benign Urological Diseases. Biomolecules. 2 December 2021;11(12):1816. doi:10.3390/biom11121816. IF: 4,879 MNiSW: 100,00
Wigner P, Szymańska B, Bijak M, Sawicka E, Kowal P, Marchewka Z, Saluk-Bijak J. Oxidative stress parameters as biomarkers of bladder cancer development and progression. Sci Rep. 23 July 2021;11(1):15134. doi:10.1038/s41598-021-94729-w. IF: 4,380 MNiSW: 140,00
Szymańska B, Sawicka E, Matuszewski M, Dembowski J, Piwowar A. The Dependence between Urinary Levels of Angiogenesis Factors, 8-Iso-prostaglandin F2α, ɣ-Synuclein, and Interleukin-13 in Patients with Bladder Cancer: A Pilot Study. J Oncol. 2 December 2020;2020:4848752. doi:10.1155/2020/4848752. IF: 4,375 MNiSW: 100,00
Sawicka E, Saczko J, Roik J, Kulbacka J, Piwowar A. Effect of Interaction between 17β-Estradiol, 2-Methoxyestradiol and 16α-Hydroxyestrone with Chromium (VI) on Ovary Cancer Line SKOV-3: Preliminary Study. Molecules. 9 November 2020;25(21):5214. doi:10.3390/molecules25215214. IF: 4,412 MNiSW: 140,00
Piwowar A, Rembiałkowska N, Rorbach-Dolata A, Garbiec A, Ślusarczyk S, Dobosz A, Długosz A, Marchewka Z, Matkowski A, Saczko J. Anemarrhenae asphodeloides rhizoma Extract Enriched in Mangiferin Protects PC12 Cells against a Neurotoxic Agent-3-Nitropropionic Acid. Int J Mol Sci. 4 April 2020;21(7):2510. doi:10.3390/ijms21072510. IF: 5,924 MNiSW: 140,00
Kubis-Kubiak A, Dyba A, Piwowar A. The Interplay between Diabetes and Alzheimer's Disease-In the Hunt for Biomarkers. Int J Mol Sci. 15 April 2020;21(8):2744. doi:10.3390/ijms21082744. IF: 5,924 MNiSW: 140,00
Wiatrak B, Kubis-Kubiak A, Piwowar A, Barg E. PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions. Cells. 14 April 2020;9(4):958. doi:10.3390/cells9040958. IF: 6,600 MNiSW: 140,00
Rorbach-Dolata A, Piwowar A. Extracellular signal-regulated kinases, P38 and c-Jun N-terminal kinases phosphorylation changes in PC12 cells with diabetic disturbances and comorbid excitotoxicity - a preliminary report. J Physiol Pharmacol. 7 October 2020;71(5). doi:10.26402/jpp.2020.5.03. IF: 3,011 MNiSW: 100,00
Piwowar A, Rorbach-Dolata A, Fecka I. The Antiglycoxidative Ability of Selected Phenolic Compounds-An In Vitro Study. Molecules. 24 July 2019 ;24(15):2689. doi:10.3390/molecules24152689. IF: 3,011 MNiSW: 100,00
Szymańska B, Marchewka Z, Knysz B, Piwowar A. A panel of urinary biochemical markers for the noninvasive detection of kidney dysfunction in HIV-infected patients. Pol Arch Intern Med. 29 August 2019;129(7-8):490-498. doi:10.20452/pamw.14905. IF: 3,007 MNiSW: 140,00
Kubis-Kubiak AM, Rorbach-Dolata A, Piwowar A. Crucial players in Alzheimer's disease and diabetes mellitus: Friends or foes? Mech Ageing Dev. July 2019;181:7-21. doi:10.1016/j.mad.2019.03.008. IF: 4,304 MNiSW: 100,00